TMEM173 Drives Lethal Coagulation in Sepsis

Academic Article


  • Zhang et al. demonstrate that TMEM173 serves as a driver of immunocoagulation in lethal infection. Inhibition of the TMEM173 pathway can correct disseminated intravascular coagulation, prevent multiple organ failure, and improve animal survival in murine sepsis models, thereby revealing a potential therapeutic target for sepsis and septic shock.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 16816491
  • Author List

  • Zhang H; Zeng L; Xie M; Liu J; Zhou B; Wu R; Cao L; Kroemer G; Wang H; Billiar TR
  • Start Page

  • 556
  • End Page

  • 570.e6
  • Volume

  • 27
  • Issue

  • 4