Two Unanticipated Pregnancies While on Cystic Fibrosis Gene-Specific Drug Therapy.

Academic Article


  • Women with cystic fibrosis (CF) desire to become pregnant and accomplish the same life goals as women without CF. The underlying pathology of CF and medications used to treat this genetically transmitted disease can affect women's reproductive potential. An interview with Ana (pseudonym), who became pregnant twice while taking the medication lumacaftor/ivacaftor (LUMA/IVA), was analyzed using thematic analysis. She described her experiences related to "Fertility and Pregnancy Surrounding LUMA/IVA," the major theme that emerged from her narrative. While there are anecdotal reports of infants conceived by women on LUMA/IVA and other CF precision medications, pregnancy rates and outcomes are not systematically tracked. Education about risks and benefits of these medications should be provided as part of comprehensive clinical care.
  • Published In


  • CFTR modulators, cystic fibrosis, pregnancy, reproductive health
  • Digital Object Identifier (doi)

    Author List

  • Ladores S; Bray LA; Brown J
  • Start Page

  • 4
  • End Page

  • 7
  • Volume

  • 7
  • Issue

  • 1