Antiphospholipid Antibody Testing in a General Population Sample from the USA: An Administrative Database Study

Academic Article


  • We sought to characterized patterns of aPL testing in a large general population sample from the United States. Using Truven Health MarketScan laboratory data from 2010–2015 we identified individuals tested for lupus anticoagulant(LA), anti-cardiolipin (aCL), and anti-beta2-glycoprotein1(aGP1). Our research was approved by the McGill institutional review board (A04-M47-12B). We identified 33,456 individuals with at least one aPL test. Among these, only 6,391 (19%) had all three tests (LA, aCL, aGP1) performed. Confirmatory aPL testing was performed at least 12 weeks later in 77%, 45%, and 41% of initially positive LA, aCL, and aGP1, respectively. Of those re-tested after ≥12 weeks, only 255 (10.6%) were found to have a confirmatory positive aPL test. These findings highlight that aPL testing may often be incompletely performed. Further investigations will be required to better understand the low rate of a confirmatory positive aPL test ≥12 weeks after the initial test.
  • Published In

  • Scientific Reports  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 7648872
  • Author List

  • Egiziano G; Widdifield J; Rahman A; Vinet E; Moura CS; Curtis JR; Bernatsky S
  • Volume

  • 10
  • Issue

  • 1