Comparison of intracervical, intrauterine, and intratubal techniques for donor insemination

Academic Article


  • Objective: To compare the efficacy of intracervical insemination (ICI), intrauterine insemination (IUI), and a combination of intratubal and intrauterine insemination (ITI/IUI) for donor insemination. Design: Prospective randomized clinical trial. Setting: The University of Michigan donor insemination program. Patients, Participants: Forty-one women undergoing donor insemination with cryopreserved sperm for either isolated male factor or male factor plus ovulatory dysfunction corrected by clomiphene citrate. Intervention: Each patient was randomly assigned to receive each of the three insemination techniques in consecutive cycles until pregnancy occurred or the patient dropped from the study. Main Outcome Measures: Cycle fecundity rates were compared using the χ2-test, and cumulative pregnancy rates (PRs) determined by life table analysis were compared using a log-rank test. Results: Cycle fecundity rate was significantly higher for IUI (18.3%) than for ICI (3.9%) or ITI/IUI (7.3%). By life table analysis, the cumulative PR for IUI was significantly higher than for ICI, but the PR for ITI/IUI was not. Conclusion: For donor insemination with cryopreserved sperm, IUI increases cycle fecundity compared with ICI. The addition of ITI to IUI, however, interferes with the apparent beneficial effect of IUI alone.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Hurd WW; Randolph JF; Ansbacher R; Menge AC; Ohl DA; Brown AN
  • Start Page

  • 339
  • End Page

  • 342
  • Volume

  • 59
  • Issue

  • 2