The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis.

Academic Article


  • It is now known that the internalization and transcytosis of low density lipoprotein (LDL) in the vessel wall occurs through molecular pathways independent of the LDL receptor. In a study recently published in Nature Communications, investigators cross-referenced results from a genome-wide ribonucleic acid interference screen with targets identified in publicly-available genome-wide association studies datasets to identify activin-like kinase 1 as a novel driver of this process. This approach has relevance to the field of atherosclerosis, and could be used as a model for the prioritization of future "hits" in large-scale genomic screens.
  • Authors

    Published In


  • activin-like kinase 1, atherosclerosis, endothelial cells, genome-wide RNAi screen, genome-wide association studies
  • Digital Object Identifier (doi)

    Pubmed Id

  • 25486250
  • Author List

  • Nanda V; Xiao S; Ye J; Leeper NJ
  • Start Page

  • 209
  • End Page

  • 211
  • Volume

  • 2
  • Issue

  • 2