In this paper, we reported a case of an 84-year-old woman with a right neck (a huge solid and cystic mass) metastasis of the left breast, after more than 22 years following her initial breast cancer diagnosis. After surgical operation, the patient recovered well. This case represents the longest interval between primary breast cancer and neck recurrence in the literatures to date. Regardless of the rare occurrence of metastatic lesions to the right neck 22 years far from the radical mastectomy (left side), the tumor metastasis way should be taken into consideration. For this exceedingly rare case, it requires further studies of mechanisms, and early diagnosis and treatment of this kind metastatic breast cancer. The case report is as followed.