DNA damage responses: Beyond double-strand break repair

Academic Article

Abstract

  • The RAG endonuclease generates DNA double strand breaks during antigen receptor gene assembly, an essential process for B- and T-lymphocyte development. However, a recent study reveals that RAG endonuclease activity affects natural killer cell function, demonstrating that such double strand breaks, and the responses they elicit, may have broad cellular effects.
  • Authors

    Published In

  • Current Biology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Bredemeyer AL; Sleckman BP
  • Start Page

  • R45
  • End Page

  • R46
  • Volume

  • 25
  • Issue

  • 1