The development of vaccine viruses against pandemic A(H1N1) influenza

Academic Article


  • Wild type human influenza viruses do not usually grow well in embryonated hens' eggs, the substrate of choice for the production of inactivated influenza vaccine, and vaccine viruses need to be developed specifically for this purpose. In the event of a pandemic of influenza, vaccine viruses need to be created with utmost speed. At the onsetof the current A(H1N1) pandemic inApril 2009, anetworkof laboratories began a race against time to develop suitable candidate vaccine viruses. Two approaches were followed, the classical reassortment approach and the more recent reverse genetics approach. This report describes the development and the characteristics of current pandemic H1N1 candidate vaccine viruses. © 2010 Elsevier Ltd.
  • Authors

    Published In

  • Vaccine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Robertson JS; Nicolson C; Harvey R; Johnson R; Major D; Guilfoyle K; Roseby S; Newman R; Collin R; Wallis C
  • Start Page

  • 1836
  • End Page

  • 1843
  • Volume

  • 29
  • Issue

  • 9