Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route

Academic Article


  • The majority of human infections associated with H7 influenza viruses have resulted in ocular and not respiratory disease. While oseltamivir has been prescribed to individuals presenting with conjunctivitis following H7 virus exposure, it is unknown if oseltamivir inhibits virus replication in ocular tissue. We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Belser JA; Sleeman K; Pearce MB; Katz JM; Gubareva LV; Tumpey TM
  • Start Page

  • 1616
  • End Page

  • 1618
  • Volume

  • 56
  • Issue

  • 3