Serum antibody response to matrix protein 2 following natural infection with 2009 pandemic influenza A(H1N1) virus in humans

Academic Article


  • Natural infection-induced humoral immunity to matrix protein 2 (M2) of influenza A viruses in humans is not fully understood. Evidence suggests that anti-M2 antibody responses following influenza A virus infection are weak and/or transient. We show that the seroprevalence of anti-M2 antibodies increased with age in 317 serum samples from healthy individuals in the United States in 2007-2008. Infection with 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) elicited a recall serum antibody response to M2 protein of A(H1N1)pdm09 in 47% of the affected 118 individuals tested. Anti-M2 antibody responses were more robust among individuals with preexisting antibodies to M2 protein. Moreover, the antibodies induced as a result of infection with A(H1N1)pdm09 were cross-reactive with M2 protein of seasonal influenza A viruses. These results emphasize the need to further investigate the possible roles of anti-M2 antibodies in human influenza A virus infection. © 2013 Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2013.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Zhong W; Reed C; Blair PJ; Katz JM; Hancock K; Aranio D; Bai Y; Browning P; Branch A; Steward-Clark E
  • Start Page

  • 986
  • End Page

  • 994
  • Volume

  • 209
  • Issue

  • 7