A highly immunogenic vaccine against A/H7N9 influenza virus

Academic Article

Abstract

  • Since the first case of human infection in March 2013, continued reports of H7N9 cases highlight a potential pandemic threat. Highly immunogenic vaccines to this virus are urgently needed to protect vulnerable populations who lack protective immunity. In this study, an egg- and adjuvant-independent adenoviral vector-based, hemagglutinin H7 subtype influenza vaccine (HAd-H7HA) demonstrated enhanced cell-mediated immunity as well as serum antibody responses in a mouse model. Most importantly, this vaccine provided complete protection against homologous A/H7N9 viral challenge suggesting its potential utility as a pandemic vaccine.
  • Authors

    Published In

  • Vaccine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Cao W; Liepkalns JS; Hassan AO; Kamal RP; Hofstetter AR; Amoah S; Kim JH; Reber AJ; Stevens J; Katz JM
  • Start Page

  • 744
  • End Page

  • 749
  • Volume

  • 34
  • Issue

  • 6