Cross-reactive antibody responses to novel h5nx influenza viruses following homologous and heterologous prime-boost vaccination with a prepandemic stockpiled a(h5n1) vaccine in humans

Academic Article


  • Recently, novel highly pathogenic avian influenza H5Nx viruses (clade caused outbreaks in US poultry. We evaluated the potential of a stockpiled A(H5N1) A/Anhui/1/2005 (clade 2.3.4) vaccine to elicit cross-reactive antibody responses to these emerging viruses. Sera from subjects who received 2 doses of MF59-Adjuvanted A/Anhui/1/2005, or 1 dose of MF59-Adjuvanted A/ Anhui/1/2005 following priming with a clade 1 vaccine were characterized by microneutralization assays and modified hemagglutination inhibition (HI) assays. Only heterologous prime-boost vaccination induced modest cross-reactive HI antibody responses to H5Nx viruses. Heterologous prime-boost may provide a more effective vaccination strategy to broaden the antibody responses to emerging viruses
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Levine MZ; Holiday C; Liu F; Jefferson S; Gillis E; Bellamy AR; Tumpey T; Katz JM
  • Start Page

  • S555
  • End Page

  • S559
  • Volume

  • 216