Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf

Academic Article


  • Pham et al. uncover mechanisms by which Batf restructures the chromatin landscape during CD4+ effector T cell differentiation. Batf controls Ctcf recruitment to lineage-specifying gene loci in an Ets1-dependent manner to promote chromatin looping and lineage-specific gene transcription, thereby identifying a heretofore unknown cooperativity of these factors in effector T cell development.
  • Published In

  • Cell Reports  Journal
  • Digital Object Identifier (doi)

    Author List

  • Pham D; Moseley CE; Gao M; Savic D; Winstead CJ; Sun M; Kee BL; Myers RM; Weaver CT; Hatton RD
  • Start Page

  • 1203
  • End Page

  • 1220.e7
  • Volume

  • 29
  • Issue

  • 5