Detection of failure of bevacizumab treatment for malignant glioma based on urinary matrix metalloproteinase activity

Academic Article


  • Although antiangiogenic treatment for malignant glioma using bevacizumab in combination with irinotecan chemotherapy has a promising effect on survival, the high incidence of increasing infiltrative tumors can be a problem in resistance to antiangiogenic therapy. In this study, we detected failure of bevacizumab treatment for malignant glioma through upregulation of metalloproteinase activity in the urine, as well as infiltrative tumors on MRI. In addition, MMP9 has been proved as a molecule that facilitates its infiltrative behavior in vivo in the brain animal model. © 2010 Japan Soceity of BrainTumor Pathology.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Takano S; Mashiko R; Osuka S; Ishikawa E; Ohneda O; Matsumura A
  • Start Page

  • 89
  • End Page

  • 94
  • Volume

  • 27
  • Issue

  • 2