Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

Academic Article

Abstract

  • Oshima et al. use hyperpolarized magnetic resonance spectroscopy to dynamically monitor tumor glycolysis and oxidative phosphorylation. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
  • Published In

  • Cell Reports  Journal
  • Digital Object Identifier (doi)

    Author List

  • Oshima N; Ishida R; Kishimoto S; Beebe K; Brender JR; Yamamoto K; Urban D; Rai G; Johnson MS; Benavides G
  • Start Page

  • 1798
  • End Page

  • 1810.e4
  • Volume

  • 30
  • Issue

  • 6