The expanding functional roles and signaling mechanisms of adhesion g protein–coupled receptors

Academic Article


  • The adhesion class of G protein–coupled receptors (GPCRs) is the second largest family of GPCRs (33 members in humans). Adhesion GPCRs (aGPCRs) are defined by a large extracellular N-terminal region that is linked to a C-terminal seven transmembrane (7TM) domain via a GPCR-autoproteolysis inducing (GAIN) domain containing a GPCR proteolytic site (GPS). Most aGPCRs undergo autoproteolysis at the GPS motif, but the cleaved fragments stay closely associated, with the N-terminal fragment (NTF) bound to the 7TM of the C-terminal fragment (CTF). The NTFs of most aGPCRs contain domains known to be involved in cell–cell adhesion, while the CTFs are involved in classical G protein signaling, as well as other intracellular signaling. In this workshop report, we review the most recent findings on the biology, signaling mechanisms, and physiological functions of aGPCRs.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Morgan RK; Anderson GR; Araç D; Aust G; Balenga N; Boucard A; Bridges JP; Engel FB; Formstone CJ; Glitsch MD
  • Start Page

  • 5
  • End Page

  • 25
  • Volume

  • 1456
  • Issue

  • 1