Origin of galactose-deficient immunoglobulin G in gingival crevicular fluid in periodontitis

Academic Article


  • Background: Periodontitis is a chronic inflammatory disease initiated by a synergistic and dysbiotic microbial community that elicits a gingival inflammatory response leading to tissue breakdown. Periodontitis shares many characteristics with other chronic inflammatory diseases, including abnormal glycosylation of immunoglobulin (Ig)G. The current authors have previously demonstrated that IgG from gingival crevicular fluid (GCF) of patients with chronic periodontitis contains galactose (Gal)-deficient IgG.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Komiyama Y; Kafkova LR; Barasch A; Shah GR; Grbic JT; Novak Z; Komiyama K; Novak J; Mestecky J; Moldoveanu Z
  • Start Page

  • 1779
  • End Page

  • 1785
  • Volume

  • 85
  • Issue

  • 12