Progressive multifocal leukoencephalopathy: Serial high-b-value diffusion-weighted MR imaging and apparent diffusion coefficient measurements to assess response to highly active antiretroviral therapy

Academic Article


  • A patient with human immunodeficiency virus-related posterior fossa progressive multifocal leukoencephalopathy had serial diffusion-weighted imaging using b-values of 1000 and 3000 before and during highly active antiretroviral therapy (HAART). High-b-value images provided a superior definition of the leading edge of the lesion and additional information about the integrity of white matter tracts. Following HAART, there was a marked reduction of lesional apparent diffusion coefficient and reconstitution of anisotropy in the affected middle cerebellar peduncle.
  • Authors

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    Author List

  • Usiskin SI; Bainbridge A; Miller RF; J├Ąger HR
  • Start Page

  • 285
  • End Page

  • 286
  • Volume

  • 28
  • Issue

  • 2