Mechanisms of action of low-dose IL-2 restoration therapies in SLE

Academic Article


  • Interleukin-2 (IL-2) shortage is a hallmark of Systemic Lupus Erythematosus (SLE). Importantly, clinical and preclinical studies demonstrate the potential clinical benefits of IL-2-based restoration therapies for the treatment of SLE. Here we discuss the immunological consequences of IL-2 deficiency in SLE patients and the mechanisms underlying the therapeutic effects of low-dose IL-2 regimens.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ballesteros-Tato A; Papillion A
  • Start Page

  • 39
  • End Page

  • 45
  • Volume

  • 61