Objectives: The aim of this study was to apply the dual-energy radiographic technique to teeth and to soft tissue simulated with Lucite and report the visual and quantitative results. Study design: High- and low-energy image pairs were exposed of aluminum and Lucite calibration wedges and human teeth sections. Reconstructed images of the calibration wedges and teeth sections were viewed and measured. Results: The aluminum reconstruction images accentuated the aluminum wedge and the teeth, whereas the Lucite reconstruction images minimized them. Correlations between the nominal direct and dual-energy measurements of the wedges and teeth thicknesses were found to be very good. The root-mean-square deviation of the dual-energy reconstructions from the measured nominal thicknesses was found to be no greater than 0.6 mm. Conclusion: These results demonstrate the feasibility of using dual energy as a means of selective cancellation of unwanted tissues and the measurement of posterior tooth density. © 2010 Mosby, Inc. All rights reserved.