Recurrent Skin Langerhan Cell Histiocytosis Successfully Treated with Indomethacin Monotherapy

Academic Article


  • Langerhans cell histiocytosis (LCH) often has a recurrent and refractory course despite multiagent treatment modalities. Common relapse treatments include intense or prolonged cytotoxic chemotherapy regimens. There are a few prior reports that the nonsteroidal anti-inflammatory drug indomethacin demonstrated activity against bone LCH. Here we report indomethacin as a successful treatment for a case of chronic skin LCH that failed multiple prior chemotherapy regimens. This experience supports the need for trials to investigate indomethacin as a treatment for LCH both in the relapsed or refractory setting as well as potential combination or maintenance therapy in newly diagnosed patients.
  • Digital Object Identifier (doi)

    Author List

  • Dhir A; Kelly DR; Watts RG; Kutny MA
  • Start Page

  • e795
  • End Page

  • e797
  • Volume

  • 42
  • Issue

  • 8