The relationship of longitudinal cognitive change to self-reported IADL in a general population

Academic Article


  • This study examined the relationship between cognitive change and instrumental activities of daily living (IADL) in a large, national, population-based sample. Cognitive change was assessed via verbal fluency, word list learning (WLL), and word list delayed recall (WLD). Incident cognitive impairment was defined by change in Six-Item Screener (SIS) status over a period of 10 years. Impaired IADL was defined as self-reported difficulty or needing assistance performing any IADL at Year 10. A one-word decrease in WLL over a 10-year span increased the odds of impaired IADL by 16% (95% CI 1.08–1.24) and incident cognitive impairment increased the odds of impaired IADL by 59% (95% CI 1.36–1.85) when adjusting for demographic factors, health-related behaviors, vascular risk factors and disease, and depressive symptoms. Cognitive change most strongly predicted impairment in managing finances (OR 2.47, 95% CI 2.04–3.00) and driving (OR 2.06, 95% CI 1.73–2.44).
  • Digital Object Identifier (doi)

    Author List

  • Passler JS; Kennedy RE; Clay OJ; Crowe M; Howard VJ; Cushman M; Unverzagt FW; Wadley VG
  • Start Page

  • 125
  • End Page

  • 139
  • Volume

  • 27
  • Issue

  • 1