Hyperreninemia and hypoaldosteronism in a child with short stature

Academic Article


  • We report a child with primary renal tubular alkalosis who had hypokalemia, profound hyperreninemia, and hypoaldosteronism. A 14-year-old girl presented with short stature and delayed puberty. Laboratory evaluation disclosed hypokalemia, hypochloremia, hypomagnesemia, alkalosis, hypocalciuria, and a markedly elevated rennin at 2859 ng/mL/h and a suppressed aldosterone at 2.5 ng/dL. Subsequently, as the serum potassium normalized, renin levels gradually declined (16.78 ng/mL/h) and, despite this renin reduction, aldosterone levels progressively increased (61.7 ng/dL). The patient's clinical course highlights the preeminent role of potassium, as a direct regulator of aldosterone synthesis, versus the indirect action of renin. This observation suggests potassium is by and large a major regulator of aldosterone synthesis in renal salt-wasting disorders.
  • Authors

    Published In

  • Endocrinologist  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 7675382
  • Author List

  • Ashraf A; McCormick K
  • Start Page

  • 313
  • End Page

  • 316
  • Volume

  • 14
  • Issue

  • 6