A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan

Academic Article


  • Studies in Caenorhabditis elegans demonstrate that disruption of the daf-2 signaling pathways extends lifespan. Similarities among the daf-2 pathway, insulin-like signaling in flies and yeast, and the mammalian insulin-like growth factor 1 (IGF-1) signaling cascade raise the possibility that modifications to IGF-1 signaling could also extend lifespan in mammals. In fact, growth hormone (GH)/IGF-1-deficient dwarf mice do live significantly longer than their wild-type counterparts. However, multiple endocrine deficiencies and developmental anomalies inherent in these models confound this interpretation. Here, we critique the current mammalian models of GH/IGF-1 deficiency and discuss the actions of GH/IGF-1 on biological aging and lifespan.
  • Authors

    Published In

  • Trends in Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Carter CS; Ramsey MM; Sonntag WE
  • Start Page

  • 295
  • End Page

  • 301
  • Volume

  • 18
  • Issue

  • 6