Capsular polysaccharide types of group B streptococcal isolates from neonates with early-onset systemic infection

Academic Article


  • The distribution of serotypes of group B streptococci (GBS) isolated from 67 infants with early-onset sepsis are described. Case-infants were assembled from 13 hospitals across the United States from 15 July 1995 to 5 February 1997 through prospective active surveillance. The distribution of GBS serotypes was Ia, 40%; Ib, 9%; II, 6%; III, 27%; V, 15%; and nontypeable, 3%. Type V occurred more frequently in the northeast region (New York and New Jersey) than in other regions (29% vs. 9%, P = .06). Conversely, type III occurred significantly less frequently in the northeast region than other regions (10% vs. 35%, P = .04). GBS types Ia, III, and V accounted for 82% of the isolates. This report supports previous observations about the emergence of GBS type V, but our data caution that conclusions about serotype distributions based on one geographic location or on a small number of patients may not be generally applicable. Continued monitoring seems necessary for the design of a GBS vaccine.
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    Author List

  • Lin CFY; Clemens JD; Azimi PH; Regan JA; Weisman LE; Philips JB; Rhoads GG; Clark P; Brenner RA; Ferrieri P
  • Start Page

  • 790
  • End Page

  • 792
  • Volume

  • 177
  • Issue

  • 3