Elimination of perinatal hepatitis B: Providing the first vaccine dose within 24 hours of birth

Academic Article


  • After the introduction of the hepatitis B vaccine in the United States in 1982, a greater than 90% reduction in new infections was achieved. However, approximately 1000 new cases of perinatal hepatitis B infection are still identified annually in the United States. Prevention of perinatal hepatitis B relies on the proper and timely identification of infants born to mothers who are hepatitis B surface antigen positive and to mothers with unknown status to ensure administration of appropriate postexposure immunoprophylaxis with hepatitis B vaccine and immune globulin. To reduce the incidence of perinatal hepatitis B transmission further, the American Academy of Pediatrics endorses the recommendation of the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention that all newborn infants with a birth weight of greater than or equal to 2000 g receive hepatitis B vaccine by 24 hours of age.
  • Published In

  • Pediatrics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Watterberg K; Benitz W; Hand I; Eichenwald E; Poindexter B; Stewart DL; Aucott SW; Puopolo KM; Goldsmith JP; Wang KS
  • Volume

  • 140
  • Issue

  • 3