HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria

Academic Article


  • Using a strategy of three-level risk stratification, a combination methylation assay of HOXA9, PCDH17, POU4F2, and ONECUT2 resulted in a positive predictive value of 100% for predicting bladder cancer in Chinese patients with hematuria. With an estimated cancer prevalence of 10% in a general hematuria population, the assay would result in an overall negative predictive value of 98%. Over half of bladder cancer cases would be predicted accurately, and ∼60% of unnecessary cystoscopy could be spared.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Wu Y; Jiang G; Zhang N; Liu S; Lin X; Perschon C; Zheng SL; Ding Q; Wang X; Na R
  • Start Page

  • 284
  • End Page

  • 291
  • Volume

  • 6
  • Issue

  • 2