Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

Academic Article


  • Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 23997784
  • Author List

  • Joly JM; Acharya D; Doppalapudi H; Kay GN; Lin CP; Maddox WR; McElderry HT; Pamboukian SV; Plumb VJ; Rajapreyar IN
  • Start Page

  • 716
  • End Page

  • 718
  • Volume

  • 24
  • Issue

  • 10