Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities

Academic Article


  • The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%. © 2005 Elsevier Ltd. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Macaev F; Rusu G; Pogrebnoi S; Gudima A; Stingaci E; Vlad L; Shvets N; Kandemirli F; Dimoglo A; Reynolds R
  • Start Page

  • 4842
  • End Page

  • 4850
  • Volume

  • 13
  • Issue

  • 16