This new algorithm for the comprehensive management of persons with type 2 diabetes mellitus (T2DM) has been developed to provide clinicians with a practical guide that considers the whole patient, the spectrum of risks and complications for the patient, and evidence-based approaches to treatment. In addition to advocating for glycemic control so as to reduce microvascular complications, this document focuses on obesity and prediabetes as the underlying risk factors for diabetes and associated macrovascular complications. It is now clear that the progressive beta-cell defect that drives the deterioration of metabolic control over time begins early and may be present before the diagnosis of diabetes (1). This document is organized into discrete sections that address the following topics: obesity, prediabetes, management of hyperglycemia through lifestyle modifications, pharmacotherapy and insulin, management of hypertension, management of hyperlipidemia, and other risk-reduction strategies. Copyright © 2013 AACE.