Preliminary crystallographic studies of four crystal forms of serum albumin.

Academic Article

Abstract

  • Several crystal forms of serum albumin suitable for three-dimensional structure determination have been grown. These forms include crystals of recombinant and wild-type human serum albumin, baboon serum albumin, and canine serum albumin. The intrinsic limits of X-ray diffraction for these crystals are in the range 0.28-0.22 nm. Two of the crystal forms produced from human and canine albumin include incorporated long-chain fatty acids. Molecular replacement experiments have been successfully conducted on each crystal form using the previously determined atomic coordinates of human serum albumin illustrating the conserved tertiary structure.
  • Authors

    Keywords

  • Animals, Crystallization, Crystallography, X-Ray, Dogs, Fatty Acids, Papio, Recombinant Proteins, Serum Albumin
  • Digital Object Identifier (doi)

    Author List

  • Carter DC; Chang B; Ho JX; Keeling K; Krishnasami Z
  • Start Page

  • 1049
  • End Page

  • 1052
  • Volume

  • 226
  • Issue

  • 3