Interpreting lung function data using 80% predicted and fixed thresholds identifies patients at increased risk of mortality

Academic Article


  • Background: The GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages for COPD use a fixed ratio of the postbronchodilator FEV 1/FVC ratio of 0.70 as a threshold to defi ne obstruction. Others advocate using the lower limit of normal (LLN) for the FEV1/FVC ratio, FEV 1, and FVC to define abnormality. This study investigated mortality in a representative sample of the US adult population with COPD by comparing abnormality determined using GOLD criteria to that determined using LLN criteria. Methods: We used baseline data from the Third National Health and Nutrition Examination Survey and follow-up mortality data. We classified subjects as obstructed, restricted, or normal based on GOLD vs LLN criteria and used Cox proportional hazards models to determine the relation between lung function impairment and mortality, adjusting for covariates. Results: The study sample included 13,847 subjects, of whom 3,774 died during the follow-up period. Of subjects classified as obstructed and restricted using GOLD criteria, 20.9% and 18.0%, respectively, were classifi ed as normal using LLN criteria. Compared with people with normal lung function, mortality was increased in the obstructed (hazard ratio, 1.46; 95% CI, 1.21-1.86) and restricted (hazard ratio, 1.94; 95% CI, 1.58-2.39) subjects classifi ed as normal using the LLN. Conclusions:In the nationally representative Third National Health and Nutrition Examination Survey data, subjects classifi ed as normal using LLN criteria but obstructed or restricted using GOLD criteria have a higher risk of mortality. © 2012 American College of Chest Physicians.
  • Published In

  • Chest  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mannino DM; Diaz-Guzman E
  • Start Page

  • 73
  • End Page

  • 80
  • Volume

  • 141
  • Issue

  • 1