NO news is good news

Academic Article


  • The recent determination of the crystal structure of microsomal cytochrome P450 reductase, a diflavin protein that shuttles electrons from NADPH to the P450 heme, represents a significant advance towards the understanding of cytochromes P450. A similar advance was made in a related enzyme system, nitric oxide synthase (NOS). The crystal structure of the NOS heme domain reveals very different architecture to that observed in P450s end offers significant insight into the production of nitric oxide, one of nature's most important regulatory molecules.
  • Authors

    Published In

  • Structure  Journal
  • Digital Object Identifier (doi)

    Author List

  • Poulos TL; Raman CS; Li H
  • Start Page

  • 255
  • End Page

  • 258
  • Volume

  • 6
  • Issue

  • 3