The effects of nicardipine in hypertensive subjects with impaired renal function

Academic Article

Abstract

  • 1. The pharmacokinetics of nicardipine and its effects on blood pressure and renal function were studied after single and multiple doses in normal subjects and in patients with impaired renal function. 2. Renal impairment was associated with higher peak plasma levels at 1 h following drug administration, a greater area under the concentration-time curve and decreased overall clearance. 3. Nicardipine produced a greater lowering of blood pressure in hypertensive subjects as compared with normals, with similar effects after single and multiple doses. 4. Nicardipine had no measurable effect on glomerular filtration rate or renal plasma flow, but the drug caused a significant increase in sodium excretion in normal and renal impaired subjects.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Lee SM; Williams R; Warnock D
  • Volume

  • 22
  • Issue

  • SUPPL. 3