Treatment of refractory adult acute leukemia with 5-azacytidine plus β-2'-deoxythioguanosine

Academic Article


  • 5-Azacytidine has established activity in the treatment of adult acute leukemia. β-2'-Deoxythioguanosine is a new purine analog which produced 6 complete remissions in 25 adequately treated patients with acute myelogenous leukemia. A pilot study indicated that these 2 agents in combination were tolerable, and suggested a role for this combination in refractory acute leukemia. A cooperative clinical trial of this regimen by the Southeastern Cancer Study Group is reported. An interim analysis has been presented.
  • Author List

  • Omura GA; Vogler WR; Bartolucci A; Neely CL; Silberman H
  • Start Page

  • 209
  • End Page

  • 210
  • Volume

  • 63
  • Issue

  • 2