Exotic mice for aging: Authors' reply

Academic Article

Abstract

  • The authors reply here to comments made by Drs. McClearn and Festing about the strengths and weaknesses of nonstandard mouse models in experimental gerontology, stressing once again the trade-off between internal and external validity. Although the use of genetically isogenic mice may, in some cases, minimize experimental costs by diminishing variance among individuals, reliance on a small number of inbred, long-domesticated stocks diminishes the external validity of a research program, i.e., the degree to which its conclusions give insights into questions of greater biological interest than the behavior of a single genotype.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Miller RA; Burke D; Austad S
  • Start Page

  • 245
  • End Page

  • 246
  • Volume

  • 20
  • Issue

  • 2