Biologic properties of cell lines derived from canine mammary carcinomas

Academic Article


  • Six canine mammary tumor cell lines (5 epithelial, 1 myoepithelial) were established from dogs with spontaneous mammary carcinomas. The cells were characterized for features of morphology and growth patterns on plastic, ultrastructure, cloning efficiency in soft agar, tumorigenicity in athymic nude mice, and hormonal receptor status. Biologic properties of the cell lines were distinct and preserved during long-term culture in vitro. All cell lines were clonogenic, 5 of 6 were tumorigenic, and 3 of 5 were receptor positive for estrogen and/or progesterone. © 1986, Oxford University Press. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Wolfe LG; Smith BB; Toivio-Kinnucan MA; Sartin EA; Kwapien RP; Henderson RA; Barnes S
  • Start Page

  • 783
  • End Page

  • 792
  • Volume

  • 77
  • Issue

  • 3