Renal cell carcinoma associated with prominent angioleiomyoma-like proliferation: Report of 5 cases and review of the literature

Academic Article


  • Five cases of renal cell carcinoma of clear cell type are presented, Fuhrmann's grade 2, associated with a peculiar stromal proliferation having angioleiomyoma-like features. This proliferation was particularly prominent at the interphase between the tumor edge and the surrounding normal tissues, in which it acquired the configuration of a tumor capsule. Four similar cases were taken from the literature. We postulate that this angioleiomyoma-like change is a tumor epiphenomenon and that it represents yet another manifestation of the well-documented capacity of renal cell carcinoma to induce vascular proliferation, probably through the secretion of angiogenic and other growth factors by the tumor cells. © 2006 Lippincott Williams & Wilkins, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Kuhn E; De Anda J; Manoni S; Netto G; Rosai J
  • Start Page

  • 1372
  • End Page

  • 1381
  • Volume

  • 30
  • Issue

  • 11