Naloxone reversal of hypotension due to captopril overdose

Academic Article


  • The hemodynamic effects of captopril and other angiotensin-converting enzyme inhibitors may be mediated by the endogenous opioid system. The opioid antagonist naloxone has been shown to block or reverse the hypotensive actions of captopril. We report a case of an intentional captopril overdose, manifested by marked hypotension, that resolved promptly with the administration of naloxone. To our knowledge, this is the first reported case of captopril-induced hypotension treated with naloxone. Our experience demonstrates a possible role of naloxone in the reversal of hypotension resulting from captopril. © 1991 American College of Emergency Physicians.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Varon J; Duncan SR
  • Start Page

  • 1125
  • End Page

  • 1127
  • Volume

  • 20
  • Issue

  • 10