The expression of retinoid receptors is altered during the development of several types of cancer. In the present study, we determined the influence of high dietary concentrations of 4-hydroxyphenylretinamide (4-HPR) and 13-cis-retinoic acid (13-cis-RA) on RAR-β mRNA expression in female mice. Expression of liver and lung RAR-β RNA increased with increasing levels of dietary retinoid (both 4-HPR and 13-cis RA). Bladder RAR-β mRNA levels, however, were significantly decreased in mice fed 13-cis RA or 4-HPR. These results suggest that feeding high levels of retinoids to mice results in tissue-specific effects on expression of RAR-β mRNA.