Identification and characterization of CD8+ suppressor T cells

Academic Article


  • It has long been appreciated that certain subsets of T cells are capable of suppressing immune reactions. Initially, such T cells were described as CD8+ suppressor T cells (Ts) and there is a vast body of research spanning 30 years that describes the immunobiology of CD8+ Ts. However, studies on CD8+ Ts have suffered from the inability to distinguish CD8+ Ts from CD8+ T cells of other phenotypes. Here we present a brief history of CD8+ Ts, a review of recent progress distinguishing CD8+ Ts as a unique subset of CD8+ T cells, and an overview of the evolving immunological context in which CD8+ Ts function.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Zimring JC; Kapp JA
  • Start Page

  • 303
  • End Page

  • 311
  • Volume

  • 29
  • Issue

  • 1-3