inflammatory myopathy and acquired immunodeficiency syndrome

Academic Article


  • A 33‐year‐old black woman with advanced acquired immunodeficiency syndrome (AIDS) presented with rapidly progressive muscle weakness and serologic and radiologic evidence of central nervous system Toxoplasma infection. Muscle biopsy revealed an inflammatory infiltrate predominantly composed of macrophages and T suppressor/cytotoxic cells. Human immunodeficiency virus major core protein (p24) was also detected in macrophages and damaged muscle cells around the inflammatory infiltrates. The patient improved clinically with glucocorticoid therapy for polymyositis and pyrimethamine and clindamycin therapy for toxoplasmosis. Copyright © 1989 American College of Rheumatology
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Nordstrom DM; Petropolis AA; Giorno R; Gates RH; Reddy VB
  • Start Page

  • 475
  • End Page

  • 479
  • Volume

  • 32
  • Issue

  • 4