Hospitalizations During a Physical Activity Intervention in Older Adults at Risk of Mobility Disability: Analyses from the Lifestyle Interventions and Independence for Elders Randomized Clinical Trial

Academic Article


  • Objectives: To determine whether moderate-intensity physical activity (PA) and health education (HE) are differentially associated with categories of hospitalizations or subgroups of participants. Design: Multicenter randomized controlled trial in which participants were randomized to a PA or HE program for an average of 2.6 years. Setting: Eight field centers. Participants: Sedentary men and women aged 70–89 with lower extremity physical limitations but able to walk 400-m in 15 minutes or less (N = 1,635). Interventions: Structured, moderate-intensity PA (n = 818) at a center (2×/wk) and at home (3–4×/wk) that included aerobic, strength, balance, and flexibility training or HE (n = 817) of educational workshops and upper extremity stretching exercises. Measurements: All-cause inpatient hospitalizations ascertained at 6-month intervals. Results: There were 1,458 hospitalizations (49.1% of PA, 44.4% of HE; risk difference = 4.68%, 95% confidence interval (CI) = −0.18–9.54; hazard ratio (HR) = 1.16, 95% CI = 1.00–1.34). The intervention effect on incident hospitalization did not differ according to race, sex, Short Physical Performance Battery score, age, or history of cardiovascular disease or diabetes mellitus. PA was associated with higher rates of hospitalization in the middle baseline gait speed category, than HE (<0.8 m/s: HR = 0.93, 95% CI = 0.76–1.14; 0.8–1.0 m/s: HR = 1.54, 95% CI = 1.23–1.94; >1.0 m/s: HR = 1.05, 95% CI = 0.67–1.65; interaction P =.005). Conclusion: A PA program in older adults at risk for mobility disability did not lead to a different risk of specific types of hospitalizations than a HE program overall. Baseline gait speed may be a marker for risk of hospitalization during a PA intervention, because individuals with moderate baseline gait speed in the PA group had slightly higher rates of hospitalization than those in the HE group. Trial Registration: identifier: NCT01072500.
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    Digital Object Identifier (doi)

    Author List

  • Marsh AP; Applegate WB; Guralnik JM; Jack Rejeski W; Church TS; Fielding RA; Gill TM; King AC; Kritchevsky SB; Manini TM
  • Start Page

  • 933
  • End Page

  • 943
  • Volume

  • 64
  • Issue

  • 5