Anti-immunoglobulin antibodies. II. Expression of individual and cross-reactive idiotypes on syngeneic and homologous anti-idiotype antibodies

Academic Article


  • Syngeneic anti-(anti-Id) antibodies were prepared against BALB/c antu-A48Id antibodies, BALB/c anti-460Id monoclonal antibodies, and A/J anti-J558 IdI monoclonal antibodies. With these anti-(anti-Id) antibodies we identified cross-reactive idiotypes on syngeneic and homologous anti-A48Id and anti-460Id anti-460ld antibodies. By contrast, the idiotypic determinants of A/J anti-J558 IdI monoclonal antibodies were not shared by other syngeneic, homologous, or xenogenic anti-J558 IdI or IdX antibodies. These results suggest that idiotype-antiidiotype reactions that serve as regulatory controls within the immune system are characteristic for each particular antigen system, strain, or species and that such interactions make the system self-limited with respect to the whole anti-Id repertoire.
  • Published In

    Pubmed Id

  • 25841721
  • Author List

  • Bona C; Kearney J
  • Start Page

  • 491
  • End Page

  • 495
  • Volume

  • 127
  • Issue

  • 2