Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

Academic Article


  • The most JH-proximal VH gene segments are used highly preferentially to form VHDJH rearrangements in pre-B-cell lines. This result demonstrates that the rate at which immunoglobulin V H gene segments recombine is influenced by their chromosomal organization, and that the initial repertoire ofVH genes expressed in pre-B cells is strikingly different from that seen in mature populations. © 1984 Nature Publishing Group.
  • Published In

  • Nature  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 25900894
  • Author List

  • Yancopoulos GD; Desiderio SV; Paskind M; Kearney JF; Baltimore D; Alt FW
  • Start Page

  • 727
  • End Page

  • 733
  • Volume

  • 311
  • Issue

  • 5988