Induction of seizures in mice by intracerebroventricular administration of the calcium channel agonist BAY k 8644

Academic Article


  • The calcium channel agonist BAY k 8644 was used to investigate the role of the calcium ion (Ca2+) in epileptogenesis. Intracerebroventricular administration of the compound induced murine seizures that were reversed by calcium channel inhibitors (CCIs) but not by anticonvulsants such as carbamazepine, pentobarbital, and diazepam. The seizures were exacerbated by phenytoin and valproic acid. Chronic administration of CCI's, previously shown to produce down-regulation of the binding of the CCI [3H]nitrendipine, resulted in augmentation of BAY k 8644-induced seizures. © 1987.
  • Authors

    Published In

  • Brain Research  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 26961365
  • Author List

  • Shelton RC; Grebb JA; Freed WJ
  • Start Page

  • 399
  • End Page

  • 402
  • Volume

  • 402
  • Issue

  • 2