Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex

Academic Article


  • Objectives: We aim to establish that interictal fast ripples (FR; 250–500 Hz) are detectable on scalp EEG, and to investigate their association to epilepsy. Methods: Scalp EEG recordings of a subset of children with tuberous sclerosis complex (TSC)-associated epilepsy from two large multicenter observational TSC studies were analyzed and compared to control children without epilepsy or any other brain-based diagnoses. FR were identified both by human visual review and compared with semi-automated review utilizing a deep learning-based FR detector. Results: Seven out of 7 children with TSC-associated epilepsy had scalp FR compared to 0 out of 4 children in the control group (p = 0.003). The automatic detector has a sensitivity of 98% and false positive rate with average of 11.2 false positives per minute. Conclusions: Non-invasive detection of interictal scalp FR was feasible, by both visual and semi-automatic detection. Interictal scalp FR occurred exclusively in children with TSC-associated epilepsy and were absent in controls without epilepsy. The proposed detector achieves high sensitivity of FR detection; however, expert review of the results to reduce false positives is advised. Significance: Interictal FR are detectable on scalp EEG and may potentially serve as a biomarker of epilepsy in children with TSC.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Bernardo D; Nariai H; Hussain SA; Sankar R; Salamon N; Krueger DA; Sahin M; Northrup H; Bebin EM; Wu JY
  • Start Page

  • 1458
  • End Page

  • 1466
  • Volume

  • 129
  • Issue

  • 7