Comparison of effects of medical and surgical therapy on survival in severe angina pectoris and two-vessel coronary artery disease with and without left ventricular dysfunction: A coronary artery surgery study registry study

Academic Article


  • This nonrandomized study compared the results of early coronary artery bypass grafting to those of initial medical therapy in a group of 2,023 patients with severe angina pectoris and 2 major epicardial coronary arteries having ≥70% diameter luminal narrowing. Medical therapy was selected for 706 patients, and 1,317 patients were treated by coronary artery bypass grafting. The 6-year survival rate was 76% for patiente treated medically and 89% for patients treated surgically (p < 0.0001). Cox multivariate analysis showed that surgical treatment was a beneficial independent predictor of survival (p < 0.001). For patients with 2-vessel coronary artery disease who had Canadian Heart Association class III and IV angina at presentation, surgical therapy provided a survival advantage for patients with impaired left ventricular function and proximal narrowing of 1 or more coronary arteries. © 1988.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Mock MB; Fisher LD; Holmes DR; Gersh BJ; Schaff HV; McConney M; Rogers WJ; Kaiser GC; Ryan TJ; Myers WO
  • Start Page

  • 1198
  • End Page

  • 1203
  • Volume

  • 61
  • Issue

  • 15