The role of lipid hydroperoxides in the myoglobin-dependent oxidation of LDL

Academic Article


  • It has previously been reported that Mb in both the iron-oxo ferryl and the ferric oxidation states can promote lipid peroxidation and lead to oxidative modification of low-density lipoprotein. The mechanism of these oxidation reactions is unclear and could involve either lipid hydroperoxide-dependent or independent reactions. In order to ascertain which of the afore-mentioned mechanisms predominates, the effects of exogenous lipid hydroperoxides on the ability of Mb, in its various oxidation states, to oxidize low-density lipoprotein has been investigated. The results suggest that oxidation proceeds through a one-electron redox cycle between met and ferryl myoglobin and that the reactions of both redox forms are at least partially dependent on lipid hydroperoxides within the LDL particle. © 1994 Academic Press, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Hogg N; Rice-Evans C; Darley-Usmar V; Wilson MT; Paganga G; Bourne L
  • Start Page

  • 39
  • End Page

  • 44
  • Volume

  • 314
  • Issue

  • 1