The purpose of this predictive correlational study was to examine antecedent (knowledge of HIV and spirituality) and psychosocial (attitude toward abstinence, attitude toward condom use, sexual self-efficacy, and perceived parental attitudes toward premarital sex) factors derived from the theories of reasoned action and planned behavior as correlates and predictors of both sexual abstinence and sexual activity. Additionally, this study identified the sexual practices (vaginal-penile, oral, and/or anal sex) in which African American adolescent females were most likely to engage. A sample of 94 African American adolescent females from low-income housing communities completed questionnaires. Major results included the following: (a) a high rate of sexual abstinence was reported, (b) age was the only significant predictor of condom use, and (c) sexual self-efficacy was not a significant predictor of engaging in sexual activity. The study results contribute to the development of HIV risk reduction programs and extend health care providers' knowledge of sexual counseling for adolescents. © 2008 Association of Nurses in AIDS Care.